Since the Dominion has little opposition in Valenwood and even less in Elsweyr, it wouldn't make sense for there to be an active opposition like there was in Skyrim. However, at a certain point in the game, the player may be visited by a ghost of a Khajiit merchant lord who laments the control of the Aldmeri Dominion and spurs the PC to start a revolution.
There would be a functioning and complex disguise system, making stealth and assassination important factors in the game.
Morality should amount to more than killing people to see how much you can get the public to hate you. Evil options should be tempting, but costly and difficult to execute, as they can be in real life. For instance, suppose you have to hunt down a group of wanderers for information and when you finally find them, they refuse to give it to you. So, you would then have the options bribing them, completing a quest for them, or burying their leader neck deep in the sand. Of course, if you take the last option, there will be repercussions, including city merchants charging you more for interrupting their supply chain and wandering merchants attacking you on sight.
Spells could be cycled through quickly using a hotkey system, allowing the player to quickly switch between spells without having to pause the game. But, in order to cast spells, the player would have to be wearing at least one "wielder's glove". The downside to this is that the number of available spells in the game would have to be trimmed and that dual-casting would no longer be possible.
Illusion spells would be similar to the ones in PERMA, involving manipulation of a phantom image of the player, instead of crappy direct illusion spells. However, there would be a few direct illusion spells like "Blind", which would inhibit the ability of a guard to see through the PC's disguise.
Were-wolves would be replaced with were-lions (or were-tigers, since Valenwood is a jungle).
