As a direct continuation from the Super Heroic ending of the first game, Adam saved humanity from Pandora's Box and did so without killing Eve. She's at the hospital and Adam constantly waits for her to wake up. Things start to get complicated when a criminal empire finds the Pandora's Box virus and starts to turn it into a biological weapon, and if that wasn't enough, Adam has to face a familiar, "damaged" foe.
Again, this game has powers instead for items and you must select them, the same as you do with items, when the situation calls for it.However, there will be regular items in this game as well, if you find them.