I ... just don't see why not. Angels and demons are popular beings. The seas of blood, stars getting knocked from the sky, and various other major catastrophes are great imagery. The anti-Christ makes a good villain, the beasts are kind of badass, in general there's a lot that could be used... but it's your story. *shrug*
Exactly what part of the process do you want tips on?
... "The apocalypse actually is not heavily talked about in the bible. It is referenced to." >_> What? The Book of Relevation, minus the first three chapters that are letters addressed to the churches, is entirely devoted to John's visions of the end times. How is that anything but heavily talked about? It's referenced in other places in the Bible, sure, but the last book is just straight up painting a (symbolism-ridden) picture of the end of the world. For the record, I've read all 66 books. It's been a while, but still, I have. The reason I suggested the Left Behind books is because they interpret the visions John saw to what scholars believe they actually meant.
... The route I would take, if I was trying to do what you are, is using the visions as a guide-line and interpreting them as creatively as possible, using some of the symbolism as clues for puzzles, and making the whole thing a survival game.