Thomas Beddoes was one of the Preeminent physicians of his time. He founded the pneumatic institution where he tried to cure diseases by inhaling gases.
First attempts (e.g. trying to cure pneumonia by inhaling cow's breath (yes!)) did not work out so well.
However it got more interesting when Beddoes hired Humphry Davy who would become perhaps the greatest chemist of his time.
Davy almost killed himself when he studied the effects of inhaling carbon monoxide.
Some things worked out better. Davy discovered the effects of nitrous oxide. This was a big deal because for the first time surgeries could be performed with anesthesia.
Davy himself used the NOX mainly for aehm... recreational purposes. And, he invited his writer friends as well, these included now-famous romantic poets such as Willam Wordsworth, Percy Shelly and others.
From time to time Samuel Taylor Coleridge visited. Who had a heroin addiction anyway because those were the days. When Coleridge took NOX with Davy while on heroin the result was a really bad trip. Thereafter he started to produce his darker works which made him wfamous, including the Rime of the Ancient Mariner ...
Day after day, day after day,
We stuck, nor breath nor motion;
As idle as a painted ship
Upon a painted ocean.
...