Played through a few games, finally ended up beating the first Ascension with the Defect after creating some sort of build that basically became nigh-immortal after the first three turns. Here's the build for power cards (some of which were acquired via other power cards lol):
The melting green donut (and his buddy that died earlier in the fight) ended up getting some good hits in early on, until the block/lightning loop sphere started generating like 100+ block every single round. This was especially disgusting when the attack came around that provides 3 attack per all block orbs channeled in the fight (which of course was a shit-ton). Getting to this point in the game, where you essentially break the fuck out of it, is routinely the most fun I get out of it.
It's also worth noting that I chose the artifact after The City that provides you with an additional energy every turn, but prevents you from seeing the enemy's next moves, which nearly killed me several times. I personally feel like Darkest Dungeon gets a little too punishing; the payoff on power never really came around when I was playing it. It's nice to earn a kick-ass build and feel like you deserve it.
It was my real name, actually. Or at least my first name.
Changed it to save myself the trouble/embarrassment. Got the win on ascension 2 with an even more ridiculous build (notice the 8 "Creative AI's" which all add power cards into my hand at the start of my turn). Was fucking around with some minions trying to see how high I could get the defense counter, when I accidentally spawned a ton of electric orbs and killed them.
The final boss for this run was called "Time Eater" and was easily the hardest of the final bosses I've encountered. His gimmick is really fucking annoying.
Just sayin, if you play as the Defect, he's got a move called Melt or whatever that removes all opponent block and does ten damage on top of that. Lol