I mean, there are games targeted towards the female population and games targeted for the male population, but at the same time, either gender could play that game. There's no sign on the kaleidoscope game that says "NO GIRLS ALLOWED TO PLAY THIS GAME." and the same for harvest moon.
Using the Harvest Moon example, there is also the other series Rune Factory which is usually targeted more towards the male populace (as shown by the fact that theres really only 1 game in that series in which you have the option of playing as a female character, and you only get that option after you beat the main storyline in which you have to play the main storyline as the male character with the female character making very few appearances until the end -I believe that is the only one-). I have played both, I know male friends who have played both, I know female friends who have played both. The line between a feminine game and a masculine game gets kinda blended in these situations.
Also for the dating sims... Again, the line gets blended a lot of times. Mainly because of the wide variety, and not only does it get blurred between the innocent-and-erotic dating sims but also in the male-and-female dating sims. I'm seeing more and more dating sims where the player has the choice of being male or female (Roomates for example, never played it but this is just what I've hear). Supposedly, in Roomates you have the choice of being the male or female protagonist and even within the male protagonist storyline you can date one of the male interests and within the female protagonists storyline you can date one of the female interests, as well as dating the opposite gender in either storylines. Because of such, it begins to blur the lines again. Not only does it give the male players a chance to play as a male and date women/men interests, but it also gives the female players a chance to play as a male and date either women/men interests, and vice versa should they chose to play as the female protagonist. Due to that, more and more people are exploring the possibilities of opening it up to both genders in many different ways.
I did play Hamtaro (the ham-ham heartbreak one), I found it adorable, and, the person who played it with me (because I struggled with some of the puzzles and just because we both found it adorable and fun) was the opposite gender. Hence both genders playing the game together even if it was considered 'girly'.
Really, it all depends on how you look at games and what kinds of games you're attracted to.